Will you help us achieve a true cure for joint injuries and arthritis?

2015 was a productive year for the Stone Research Foundation with much to celebrate. We are changing the treatment of osteoarthritis (OA) and preventing it from occurring by improving articular cartilage, meniscus and ligament replacement techniques. We need your help to achieve a true cure.

Contributions from our donors helped us complete three outcome studies and launch the first phase of an important multi-phase study.  All reflect the importance and value of our biologic orthopedic solutions.  This year we:

  • Completed a 10-23 year follow-up study of patients receiving the articular cartilage paste graft in which patients reported improvements in pain and function levels for an estimated average of 16 years.
  • Published a long term follow-up study of meniscus allograft transplantation in which we found that patients were able to participate in sporting activities with reduced levels of pain for up to 15 years postoperatively.
  • Published, in collaboration with physicians from Harvard Medical School, a study analyzing the treatment guidelines for knee and hip OA with the goal of building support for biologic procedures within the orthopaedic community.
  • Launched a study to determine the cellular composition of the paste graft to refine and improve the technique.

Through wider use of available cartilage repair options when OA is first diagnosed, we believe that suffering from chronic OA can be avoided. 

In 2016 the Foundation, with your support,  will launch additional studies to quantify the benefit of filling meniscus and ligament grafts with stem cells and growth factors prior to implantation; and a study on the ability of anabolic agents to prevent muscle atrophy following surgery. We would be happy to discuss the details of those studies with you.

We are asking you to support these important initiatives by making a donation today.  There are three ways to give:

  1. Donate to the Stone Research Foundation General Fund, which supports patient outcome study preparation and publication and education programs.  The operating budget for 2016 is $250,000.
  2. Donate to the Research Fund, which supports the paste graft and cell seeding research programs.  The budget for each multi-year program is between $300,000 and $550,000.
  3. Create an endowment, which ensures that our work can continue for years to come. We are currently seeking $10 million to fund the ongoing research and education missions of the Foundation.

Will you help solve joint injuries and arthritis?

Cartilage Repair: Is it possible? An update from the Orthopedic Research Society symposium

As a part of this year’s Orthopaedic Research Society meeting, Dr. Kevin R. Stone was honored to join Dr. Gordana Vunjak-Novakovic as an invited speaker in a special translational research symposium session entitled “Cartilage Repair: Is it possible?” Read more on how these two leaders of their respective fields have been working to answer this question for the last two decades.

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A look back at 2014

2014 was a successful year for the Stone Research Foundation. Generous donor contributions helped us deliver on both our research and education goals to advance and promote biologic orthopedic solutions.

Some of the 2014 highlights:

Meniscus Transplantation in Athletes Study
In September, we completed a long-term outcome study of meniscal transplants in athletes with osteoarthritis, which showed that the procedure can get people back to sports for up to 15 years. The study was publish in the journal of Knee Surgery, Sports Traumatology, Arthroscopy.
Learn more>

10-20 Year Articular Cartilage Paste Graft Study
We completed a 10-20 year outcome study of articular cartilage paste grafting for traumatic and arthritic knee lesions. Cartilage repair procedures are promoted as extremely promising solutions for patients seeking to avoid or delay knee replacement. However, most techniques are indicated for isolated defects, not more widespread damage and there are few outcome studies on biologic procedures longer than short- to medium-term. This follow-up study showed that paste grafting was able to provide improvements in pain, function, and activity levels for patients for up to 20 years. Combined with its low cost, the paste graft is a viable long-term treatment option for severe cartilage injuries.

Paste Grafting for Failed Osteochondritis Dissecans Lesion Repairs
We completed a study on the outcomes of the articular cartilage paste graft technique for previously failed surgical treatments of knee Osteochondritis dissecans lesions. MRI images of study patients confirmed that the paste graft procedure was able to restore the cartilage surface. Patients in the study reported significant reduction in pain and significant improvements in function and activity levels compared to before undergoing paste grafting.

Fellowship program
Over four months this year, we mentored Indian orthopedic surgeon, Irfan S. Sheikh, MBBS, DNB Orthopedics for our clinical and research fellowship. During his time with us, Dr. Sheikh participated in clinical and surgical observation with Dr. Stone; development and execution of research studies; and a surgical training lab to learn biologic surgical techniques.
Learn more>

Meniscus Defect Repair Study
In July, we launched the first phase of a study to evaluate infusing segments of donor meniscus tissue with a patient’s own stem cells for repair of large and complex meniscus tears. The results of this study have the potential to increase the indication for surgical repair of the meniscus, allowing surgeons to preserve the native meniscus more often, rather than having to remove it.

Biologic Surgical Techniques Workshop
In April, we hosted a hands-on workshop teaching biologic surgical techniques to attending surgeons. Dr. Stone provided hands-on, one-on-one training to workshop attendees, sharing valuable tips and tricks of the three-tunnel technique for meniscus transplantation.

Presented as Keynote Speaker at Chinese Meniscus Surgery Conference
Dr. Stone presented as the keynote speaker for Chinese surgeons in Beijing on meniscus transplantation theory, practice and results. His time at the event included a teaching lab, and private meetings with surgeons and medical administrators.

We couldn’t have done this without you!

We are grateful for the commitment of our donors. Charitable gifts to the Stone Research Foundation help support our ability to conduct ground-breaking science; attract world-class collaborators; develop new methods of using stem cells and growth factors to speed healing; solve the problem of post-traumatic arthritis; inspire students and surgeons who come to the Foundation; lecture around the world to teach surgeons; and bring cost effective care to the developing world.

With your ongoing help, we are positioned to continue these successes into 2015.

The Case for Articular Cartilage Paste Grafting

The Case for Articular Cartilage Paste Grafting

Since 1991, the "Articular Cartilage Paste Grafting" technique has provided a simple and cost-effective method to treat acute and chronic osteocartilaginous lesions in both healthy and arthritic knees. Independent review of repair tissue biopsies revealed that one-third of the lesions had grown cartilage indistinguishable from normal, one-third appeared to be a mix of fibrocartilage and hyaline cartilage and one-third appeared to be solely fibrous tissue. Several studies have extended our findings on the paste grafting procedure and we are excited to share these with you in this article.

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